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Huber-Ruano I, Calvo E, Mayneris-Perxachs J, Rodrguez-Pea MM, Ceperuelo-Mallafr V, Ced L, Nez-Roa C, Miro-Blanch J, Arnoriaga-Rodrguez M, Balvay A, Maudet C, Garca-Roves P, Yanes O, Rabot S, Grimaud GM, de Prisco A, Amoruso A, Fernndez-Real JM, Vendrell J, Fernndez-Veledo S

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Despite the compatibility of MT-II with a nasal spray format and the advantages of nasal delivery of peptides, there are some important factors to consider to ensure consistent dosing and maximal effectiveness: The area within the nasal membrane responsible for absorption is small and can accommodate a relatively limited volume of liquid/aerosol delivered via spray